Coleus forskolii and TTA.
Neither is a thermogenic, but they do boost calorie and fat usage and seem to work synergistically a bit.
These are the notes I have on them:
FORSKOLIN
Forskolin works by activating the enzyme adenylate cyclase (1). Lipolytic hormones such as epinephrine (adrenalin) activate adenylate cyclase as well, but forskolin does not have the same CNS effects, so it essentially bypasses the step that is associated with the unwanted side effects (nervousness, restlessness) we find with other fat loss agents that function by increasing lipolytic hormone levels. When adenylate cyclase is activated it then converts to cyclic adenosine monophosphate (cAMP). This increase in cAMP levels has many effects on the body, but the one that is of most interest for fat loss is the activation of cAMP-dependent protein kinase, which in turn activates hormone-sensitive lipase (HSL), which ultimately breaks down fat and releases it as free fatty acids in the bloodstream (1). This process is commonly referred to as the "cAMP cascade" or "lipolytic cascade." On top of all this, there is an added bonus – forskolin also acts as a thyroid stimulant, most likely through a cAMP-mediated process (8).
TTA
TTA may also be very promising among anti-fat supplements, because it appears to burn fat independent of exercise; preliminary results suggest that the body simply appears to "remove" fat from itself instead of needing to have it burned off with physical activity. TTA is one of a number of bodybuilding health products meant to specifically reduce body fat and therefore increase muscle definition. Although it does not appear to encourage muscle growth on its own, it does encourage lipolysis, or fat burning. Best of all, it appears to do this without forcing your body to use fat stores for energy, which means that it is simply forced out of the body instead of having to be burned off. This, in turn, can make your workouts even more effective, because during a workout, you can burn off current caloric intake instead of burning excess fat stores. This can make workouts much more efficient because you will see results faster; because you're burning off what you eat instead of burning off fat stores, you should lose excess weight much more quickly and therefore see greater definition much more quickly as well. TTA also appears to make insulin work more effectively and increase insulin sensitivity, which means less insulin is excreted during each release. Insulin as a hormone appears to make the body both build and maintain fat stores; this may mean that TTA is further beneficial as a fat loss product for this reason.
