Honestly, I rarely get laid on the first date. The only girls I've had ONS with did not involve a date beforehand, nor were they girls I wanted to do stuff with beyond just sex.
However, I'm a GREAT second date closer. The reason for this is because, when I go out with a girl (and I tend to go for nice girls, not rebellious chicks with attitude), I'm already of the mindset that almost every guy she's been out with in life has tried to bang her on the first date. So, I purposefully do NOT push for sex that hard the first time out. I use the first date to show them a good time, what a cool guy I am, and push away any guards they may have up about me just being with them for sex.
When I get to the end of the date and DON'T push for sex, on some level it's gotta mess with their head. On one hand they're relieved I didn't make them get physical... but on the other hand, they're wondering if maybe it's because I didn't find them desirable. So, they spend the second date trying to prove to themselves that they're still desirable, which usually results in them having sex with me.
So, to answer the question: I handle last minute resistance by being indifferent (as I said on another post earlier today). If they decide they don't want to have sex, I don't make them feel bad about it and continue treating them like I was treating them the whole date; if they decide they DO want sex... we have sex, and I continue treating them like I was treating them the whole date.