Ohhhhh yes, many, many times. Whats worse is that sometimes its family!
I grew in a lower middle-class family where perfect was never good enough, that's a killer right there. I wasn't encouraged or rewarded for doing good, it was expected. That changed when they realized there was a problem, I broke down in school once when I was far younger because I made a B+ on a test.
Ive had more than one occasion where i would be hanging out in our social circle which included my cousin. He was probably the worst about making snide remarks on my looks (i work out and could stand to lean out some more, but has severe trouble controlling his weight), me not having a girl while he did, you get the picture. His standards in women are a far cry from mine, he'll take any slutty pvssy, and I typically only enjoy women of slightly higher value, nor have I ever felt the NEED for a woman. Granted, this only happened while women were around, especially ones who were obviously intetested in me. This was a major hit to my ego, my game, and my general well-being. I finally came to the assumption that he made attempts to lower my value, therefore attemping to increase his. I just hung around him less and learned to shrug insults off otherwise, I learned my value. He has since stopped doing such things in my presence. He really isn't an awful feller, and would give you the shirt off his back otherwise. His ego may have been bruised at one point as well, a few of his crushes have migrated towards me on a few occasions.
My slightly younger brother has as well, although far more rare. I usually just called him out on his ****.
Most of my friends have always been very supportive of me though, I choose them wisely.
A lot of these things were hard hits on the ego and self esteem, but I'm on top of my education, career, health, and finances now. You live learn, and get over that crap. Not to mention, I may not be a ladies man, but I don't do too badly eigther.