Open regular just talk to all of them. (If its a 2 or 3 set) Tease your target more so you have some sexual tension. But if its a huge set it isn't really needed to engage them all. But its just like opening a lone wolf.
Also could merge sets if you feel that you need to keep one of them occupied by having a pawn, pivot, or wingman.(Say you open a 2set there isn't a way for you to isolate the target without the other getting bored)
I find group sets more fun, but thats just my opinion.