There are a ton of factors that go into losing/gaining weights. Water,food,bathroom trips,blood flow and so on. I've had a BB friend who lost 10 pounds over the course of 1 week of being really sick so 15 is pretty far fetched.
Definitely possible... You do however, risk electrolyte disturbances/dehydrations that have the potential to become life threatening if life untreated. Should definitely get to the hospital if you have that kind of diarrhea.
Cholera, Camylobacter spp., Rotavirus (more so in kids), entertoxigenic E. coli can all cause serious diarrhea.
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