JoeJoe85 said:
I'm taking a "refuse to lose" approach to this.
Be persistent but drop the "I'm not a loser!" attitude, because you really have nothing to lose by pursuing her.
The following info will only help you if you change your initial attitude:
1. Flirt with her and don't be afraid to disagree (honestly disagreeing)
2. Walk out of class with her; don't let her escape so easily!
3. Get her number and arrange a time to "hangout" so that you can build comfort in a non-academic environment because being in class interrupts your game.
I was talking to a couple girls in class today and the teacher was completely on my ass when I was flirting with one of them next to me. Luckily, I took care of the situation and didn't risk getting called out again so I didn't start up any more conversation with the girl.
Pickup in classes is an excellent opportunity! You just have to go into comfort outside of the classroom, while maintaining attraction and rapport in the classroom.