The best way to avoid the worst types of women in the city (validation hungry underage girls, guido chicks, and bridge and tunnel trashy) is to avoid the Meatpacking District popular spots. I started not to bother with those spots unless it was PhD or maybe Le Bain, main reason being you can meet hot girls who are visiting there. Rest of the area is just Jersey folks flooding into NYC to chill with their old crew.
Murray Hill can occasionally be decent but man, I have to say, about going out in NYC for 8 months straight at one point I noticed a trend.
You get a ton of kids from Jersey and Long Island at the party bars. Typical dudebro tryhards and stuck up princesses galore. I got into a habit in NYC of avoiding the popular go to spots because of this very reason. All it attracted were fake wealth try-hards from Jersey and not from the city itself.
The only saving grace of going to Mr. Purple or Meatpacking District was that occasionally you did run into a Euro chick who was kind of going "WTF" while in those places. After having enough drunk dude bros try to talk to her, a cool guy with game was golden.
For how cosmopolitan NYC is supposed to be, especially Manhattan, I was thrown off by the dudebro presence in a lot of the nightlife in the city. I mean tryhard dudebros which at times made you feel like you were in a southern college town or something.
Still a great city though and a guy with the right mindset and his act together can do some serious damage, easily top 3 city in the US. Just avoid anywhere that is not Brooklyn or Manhattan though, it gets very family-oriented and residential outside of that.